Syndol Headache Relief Tablets 30s

Swallow the tablets whole with water. Do not chew.

• Adults: Take 2 tablets every 4-6 hours as required. Do not take more than 8 tablets in 24 hours.
• Children aged 16-18 years: Take 1-2 tablets every 6 hours as required. Do not take more than 8 tablets in 24 hours.
  Children aged 12-15 years: Take 1 tablet every 6 hours, as required. Do not take more than 4 tablets in 24 hours. Do not take more frequently than every 6 hours.

Do not use for more than 3 days. If you need to use this medicine for more than three days you must speak to your doctor
or pharmacist.

• Active Ingredients: Paracetamol 500mg, caffeine 30mg and codeine phosphate 8mg.
  Other Ingredients: Povidone, maize starch, methylcellulose, talc, purified water, calcium stearate, methylhydroxypropylcellulose and polyethylene glycol.

• Syndol Headache Relief Tablets contain codeine which can cause addiction if you take it continuously for more than three days. This can give you withdrawal symptoms from the medicine when you stop taking it.
• This medicine contains paracetamol. Do not take anything else containing paracetamol while taking this medicine.
• Talk to a doctor at once if you take too much of this medicine even if you feel well. This is because too much paracetamol can cause delayed, serious liver damage. Go to your nearest hospital casualty department. Take your medicine and this leaflet with you.
• If you take this medicine for headaches for more than three days it can make them worse. Always take this medicine exactly as described in the leaflet or as your doctor or pharmacist has told you.
• Do not drink alcohol (beer, wine, spirits etc) while taking this product.
• These tablets might cause drowsiness. If you are affected, do not drive or operate machinery.
• The medicine can affect your ability to drive as it may make you sleepy or dizzy. Do not drive while taking this medicine until you know how it affects you. It may be an offence to drive when taking this medicine. Talk to your doctor or pharmacist if you are not sure whether it is safe for you to drive while taking this medicine. Details regarding a new driving offence concerning driving after drugs have been taken in the UK may be found here: https://www.gov.uk/drug-driving-law.

Do not take Syndol Headache Relief Tablets if you:

• Are allergic to paracetamol, codeine, caffeine or any of the other ingredients of this medicine.
• Have acute asthma.
• have severe respiratory disease.
• Suffer from alcoholism.
• Have had recent bile duct surgery (e.g. gall stones).
• Suffer from paralytic ileus, where your bowel has ceased to function.
• Have recently had a head injury or raised pressure in the skull.
• Are breastfeeding.
• Have been told by your doctor that you are a CYP2D6 ultra metaboliser.
• Are under 18 years and have had your tonsils or adenoids removed.

Talk to your doctor or pharmacist before taking this medicine, if you:

• Suffer from kidney or liver problems, including alcoholic liver disease.
• Have an enlarged prostate gland.
• Suffer from low blood pressure.
• Suffer from inflammatory or obstructive bowel disorders such as constipation, diarrhoea or bloating.
• Suffer from an underactive thyroid gland.
• Are elderly or debilitated.

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, like:

• Medicines to treat high cholesterol levels which reduce the amount of fat in the blood such as colestyramine.
• Medicines to control feeling sick or being sick such as metoclopramide or domperidone.
• Medicines called anti-coagulants, which are used to thin the blood such as warfarin, aspirin or other coumarins - you may take occasional doses of paracetamol but should consult your doctor if you need to take it on a regular basis.
• Cimetidine, a medicine to treat heartburn or peptic ulcers.
• Tricyclic antidepressants, which are medicines used to treat depression e.g. amitriptyline and imipramine.
• Antipsychotic medicines used to treat mental illness e.g. chlorpromazine and risperidone.
  Quinidine or mexiletine, used to treat heart problems.
• Antidepressant drugs called monoamine oxidase inhibitors (MAOI’s) - these are medicines such as phenelzine and moclobemide.
• The antibiotic chloramphenicol.
• Other CNS depressant drugs such as sodium oxybate.
• Barbiturates and benzodiazepines which are medicines to calm you down or to help you sleep (e.g. mephobarbital, pentobarbital, diazepam and alprazolam).
• Medicines for diarrhoea and tummy cramps as taking these at the same time as Syndol Headache Relief Tablets may make you constipated.
• Medicines such as atropine, procyclidene, or hyoscine which are used to treat problems with gut movement. Taking these at the same time as Syndol Headache Relief Tablets may make you severely constipated and may make it difficult for you to pass urine.
• Some antihistamines which may be used in cough/cold remedies and anti-allergy products. Taking these at the same time as paracetamol, caffeine and codeine tablets may make you  severely constipated and may make it difficult for you to pass urine.
• Naltrexone – used in the treatment of drug dependence.
• Flucloxacillin (antibiotic), due to a serious risk of blood and fluid abnormality (high anion gap metabolic acidosis) that must have urgent treatment and which may occur particularly in case of severe renal impairment, sepsis (when bacteria and their toxins circulate in the blood leading to organ damage), malnutrition, chronic alcoholism, and if the maximum daily doses of paracetamol are used.

Pregnancy and breastfeeding

• Do not take this medicine if you are breastfeeding.
• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.