Perrigo Ibuprofen 200mg/5ml Oral Suspension 100ml

The recommended doses of ibuprofen oral suspension are as follows: 

• Children aged 7-9 years: One 5ml spoonful up to three times in 24 hours.
• Children aged 10-12 years: One 5ml spoonful and one 2.5ml spoonful up to three times in 24 hours.

Do not give to children under 7 years of age, or  those weighing less than 20kg

Separate the doses evenly (every 6-8 hours).

Leave at least 4 hours between doses.

Do not give more than 3 doses in any 24 hour period

• Active Ingredient: Ibuprofen 200mg per 5ml.
• Other Ingredients: Glycerol (E422), xanthan gum, liquid maltitol (E965), polysorbate 80, saccharin sodium (E954), citric acid monohydrate, sodium benzoate (E211), magnesium aluminium silicate, purified water and strawberry flavour (contains propylene glycol).

• Serious skin reactions (such as Steven-Johnson syndrome) have been reported very rarely in association with the used of NSAIDs. The use of this medicine should be stopped immediately at the first appearance of skin rash, mucosal lesions, or any other signs of allergic reactions.
• During chicken pox (varicella) it is advisable to avoid use this medicine.
• Side effects may be minimised by using the minimum effective dose for the shortest duration.
• In general terms, the habitual use of (several sorts of) analgesics can lead to lasting severe kidney problems. The risk may be increased under physical strain associated with loss of salt and dehydration. Therefore it should be avoided.
• Prolonged use of any type of painkiller for headaches can make them worse. If this situation is experienced or suspected, medical advice should be obtained and treatment should be discontinued. The diagnosis of medication overuse headache (MOH) should be suspected in patients who have frequent or daily headaches despite (or because of) the regular use of headache medicines.
• NSAIDs may mask symptoms of infection and fever.
• Gastro-intestinal bleeding, ulceration or perforation, which can be fatal, has been reported with all NSAIDs at anytime during treatment, with or without warning symptoms or a previous history of serious gastro-intestinal events. When gastrointestinal bleeding or ulceration occurs, the treatment should be stopped immediately. The risk of gastrointestinal bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation and in the elderly. These patients should commence treatment on the lowest dose available. Combination therapy with protective medicines (e.g. misoprostol or proton pump inhibitors) should be considered for those patients, and also those requiring concomitant low-dose aspirin, or other medicines likely to increase gastrointestinal risk.
• Anti-inflammatory/pain-killer medicines like ibuprofen may be associated with a small increased risk of heart attack or stroke, particularly when used at high doses. Do not exceed the recommended dose or duration of treatment. You should discuss your treatment with your doctor or pharmacist before taking this medicine if you:
  • Have heart problems including heart failure, angina (chest pain), or if you have had a heart attack, bypass surgery, peripheral artery disease (poor circulation in the legs of feet due to narrow or blocked arteries), or any kind of stroke (including 'mini-stroke' or transient ischaemic attack “TIA”).
  • Have high blood pressure, diabetes, high cholesterol, have a family history of heart disease or stroke, or if you are a smoker.
• Consult a doctor before using this medicine if any of the above mentioned conditions concern your child.
• You should not drink alcohol while using Perrigo Ibuprofen 200mg/5ml Oral Suspension. Some side effects, such as those affecting the gastrointestinal tract or the central nervous system can be more likely when alcohol is taken at the same time as this medicine.
• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Do not use this medicine if you are in the last 3 months of pregnancy. Avoid the use of this medicine in the first 6 months of pregnancy unless your doctor advises you otherwise. Breastfeeding: only small amounts of ibuprofen and its decomposition products pass into breast milk. This medicine may be used during breastfeeding, if it used at the recommended dose and for the shortest possible time.
• Perrigo Ibuprofen 200mg/5ml Oral Suspension belongs to a group of medicines (NSAIDs) which may impair the fertility in women. This effect is reversible on stopping the medicine.
• Perrigo Ibuprofen 200mg/5ml Oral Suspension contains maltitol (E965) which may have a mild laxative effect (calorific value 2.3 kcal/g).  If you have been told that you or your child has an intolerance to some
   sugars, contact your doctor before taking/giving this medicine.
• The elderly have an increased risk of adverse events when taking NSAIDs, particularly those relating to the stomach and bowel. Patients with a history of gastro-intestinal toxicity, particularly when elderly, should report any unusual abdominal symptoms (especially gastrointestinal bleeding) particularly in the initial stages of treatment.

Do not give Perrigo Ibuprofen 200mg/5ml Oral Suspension to children who:

• Are allergic to ibuprofen or other similar painkillers (NSAIDs) or to any of the other ingredients of this medicine.
• Have ever suffered from shortness of breath, asthma, a runny nose, swelling on their face and/or hands or hives after using Aspirin or other similar painkillers (NSAIDs).
• Have ever had a gastrointestinal bleeding or perforation, related to previous use of NSAIDs.
• Currently have or have had recurrent stomach/duodenal ulcers (peptic ulcers) or bleeding (two or more episodes of proven ulceration and bleeding).
• Have severe liver or severe kidney failure.
• Have severe heart failure.
• Have bleeding of the brain (cerebrovascular bleeding) or other active bleeding.
• Have unclarified blood-formation disturbances.
• Have severe dehydration (caused by vomiting, diarrhoea or insufficient fluid intake).

Do not take if you are in the last 3 months of pregnancy.

Talk to your doctor or pharmacist before using Perrigo Ibuprofen 200mg/5ml Oral Suspension if your child:

• Has certain hereditary blood formation disorders (e.g. acute intermittent porphyria).
• Suffers from coagulation disturbances.
• Has certain diseases of the skin (systemic lupus erythematosus (SLE) or mixed connective tissue disease).
• Has or has ever had bowel disease (ulcerative colitis or Crohn's disease) as these conditions may be exacerbated.
• Has ever had or currently has high blood pressure and/or heart failure.
• Has reduced kidney function.
• Has liver disorders. In prolonged administration of this medicine regular checking of the liver values, the kidney function, as well as of the blood count, is required.
• Is taking medicines which could increase the risk of ulceration or bleeding, such as oral corticosteroids (such as prednisolone), medicines for thinning the blood (such as warfarin), selective serotonin-reuptake inhibitors (a medicine for
• depression) or anti-platelet medicines (such as aspirin).
• Is taking another NSAID medicine (including COX-2 inhibitors such as celecoxib or etoricoxib) as taking these together should be avoided.
• Has or has had asthma or allergic diseases as shortness of breath may occur.
• Suffers from hayfever, nasal polyps or chronic obstructive respiratory disorders an increased risk of allergic reactions exists. The allergic reactions may present as asthma attacks (so-called analgesic asthma), Quincke's oedema or urticaria.
• Has just undergone major surgery as medical surveillance is required.
• Is dehydrated as there is a risk of kidney problems in dehydrated children.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. In particular, tell them if you are taking:

• Other NSAIDs including COX-2 inhibitors - this may increase the risk of side effects.
• Digoxin (for heart insufficiency) - the effect of digoxin may be enhanced.
• Glucocorticoids medicines containing cortisone or cortisone-like substances) - this may increase the risk of gastrointestinal ulcers or bleeding.
• Anti-platelet medicines - this may increase the risk of bleeding.
• Aspirin (low dose) - the blood-thinning effect may be impaired.
• Medicines for thinning the blood (such as warfarin) - ibuprofen may enhance the effects of these medicines.
• Phenytoin (for epilepsy) - the effect of phenytoin may be enhanced.
• Selective serotonin reuptake inhibitors (medicines used for depression) - these may increase the risk of gastrointestinal bleeding.
• Lithium (a medicine for manic depressive illness and depression) - the effect of lithium may be enhanced.
• Probenecid and sulfinpyrazones (medicines for gout) - the excretion of ibuprofen may be delayed.
• Medicines for high blood pressure and water tablets - ibuprofen may diminish the effects of these medicines and there could be a possible increased risk for the kidney.
• Potassium sparing diuretics e.g. amiloride, potassium canreoate, spironolactone, triamterene - this may lead to hyperkalaemia.
• Methotrexate (a medicine for cancer or rheumatism) - the effect of methotrexate may be enhanced.
• Tacrolimus and cyclosporine (immunosuppressive medicines) - kidney damage may occur.
• Zidovudine: (a medicine for treating HIV/Aids) - the use of this medicine may result in an increased risk of bleeding into a joint or a bleeding that leads to swelling in HIV (+) haemophiliacs.
• Sulfonylureas (antidiabetic medicines) - the blood sugar levels can be affected.
• Quinolone antibiotics - the risk for convulsions (fits) may be increased.
• Voriconazole and fluconazole (CYP2C9 inhibitors) used for fungal infections - the effect of ibuprofen may increase. Reduction of the ibuprofen dose should be considered, particularly when high-dose ibuprofen is administered with either voriconazole or fluconazole.
• Baclofen - Baclofen toxicity may develop after starting ibuprofen.
• Ritonavir – it may increase the plasma concentrations of NSAIDs.
• Aminoglycosides - NSAIDs may decrease the excretion of aminoglycosides.