Accrete D3 1500mg/400iu Film-Coated Tablets 60s

Always use this medicine exactly as described in the leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Adults and the elderly:

• One tablet twice daily (e.g. one tablet in the morning and one tablet in the evening).
  It is recommended to take the tablet within one and a half hours of a meal with a glass of water or juice, without chewing it.
• The tablet can be broken in half, if needed.

• Active Ingredients: Colecalciferol 400IU (equivalent to 10 micrograms) and calcium 600mg (as calcium carbonate 1500mg).
• Other Ingredients: Tablet core: magnesium stearate, crospovidone (Type A), copovidone (K-value: 25.2-30.8), microcrystalline cellulose, sucrose, gelatin, all-rac-a-tocopherol (E307), hydrogenated soya-bean oil, maize starch. Coating: yellow iron oxide (E172), hypromellose (15 mPa s), titanium dioxide (E171), macrogol 3350, talc.

• Oxalic acid (found in e.g. spinach, sorrel and rhubarb), phosphate and phytic acid (found in whole cereals) may inhibit calcium absorption. The patient should not take Accrete D3 1500mg/400iu Film-Coated Tablets within two hours after eating foods rich in oxalic acid, phosphate and phytic acid.
• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. During pregnancy, the daily intake should notexceed 1500 mg calcium and 600 IU (International Unit) vitamin D. In pregnant women, overdoses of calcium and vitamin D should be avoided as permanent hypercalcaemia is related to adverse effects on the developing foetus. During pregnancy, Accrete D3 1500mg/400iu Film-Coated Tablets should be used in the recommended doses only in cases of calcium and vitamin D3 deficiency. In other cases the daily dose of Accrete D3 1500mg/400iu Film-Coated Tablets must not exceed one tablet per day. Accrete D3 1500mg/400iu Film-Coated Tablets can be used during breastfeeding, but your doctor should be informed as calcium and vitamin D gets into the breast milk. This should be considered when giving additional vitamin D to the child.
• Accrete D3 1500mg/400iu Film-Coated Tablets contain hydrogenated soya oil. If you are allergic to peanut or soya, do not use this medicinal product.
• Accrete D3 1500mg/400iu Film-Coated Tablets contain sucrose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

Do not take Accrete D3 1500mg/400iu Film-Coated Tablets:

• If you are allergic to active substances or any of the other ingredients of this medicine.
• Accrete D3 film-coated tablets contain hydrogenated soya oil. lf you are allergic to peanut or soya, do not use this medicinal product.
• If you have kidney stones.
• If you have kidney failure or severe renal impairment.
• If you have calcium deposits in your kidneys (nephrocalcinosis).
• If you have excessive amounts of vitamin D in the blood.
• If you have chronically increased calcium level in your urine or elevated blood-calcium level
• If you have disturbed parathyroid hormone metabolism.
• If you have sarcoidosis (an inflammatory disease of unidentified origin characterised by formation of cell agglomerates (lumps) in different locations.
• If you are an immobilised patient with osteoporosis.
• If you are taking thiazide diuretics (to treat high blood pressure).
• If you are taking cardiac glycosides (to treat heart conditions) such as digoxin.
• If you are less than 18 years of age.

Talk to your doctor or pharmacist before taking Accrete D3 1500mg/400iu Film-Coated Tablets:

• If you have kidney disease or impaired kidney function.
• If you have sarcoidosis (an inflammatory disease of unidentified origin characterised by formation of cell agglomerates (Iumps) in different locations).
• If you are prone to development of kidney stones.
• If you are an immobilised patient with osteoporosis

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Consult your doctor or pharmacist if you use:

• Other medicines or food supplements containing vitamin D or calcium, because concomitant (accompanying) use of such products with Accrete D3 1500mg/400iu Film-Coated Tablets may lead to a significant elevation of bloodcalcium levels and cause adverse effects that may be harmful. During the treatment with Accrete D3 1500mg/400iu Film-Coated Tablets, do not use any other products containing vitamin D or calcium without medical advice.
• Thiazide diuretics.
• Systemic (per os [oral] or injection) corticosteroids (anti-inflammatory drugs).
• Cardiac glycosides (used for the treatment of cardiac [heart] failure).

Take special care if you use:

• Ion exchange resins such as cholestyramine or laxatives such as paraffin oil, as these medicines may reduce the gastrointestinal absorption of vitamin D.
• Tetracycline containing preparations (antibiotics), as calcium carbonate may interfere with their absorption. Therefore, tetracycline preparations should be administered at least two hours before or four to six hours after using of Accrete D3 1500mg/400iu Film-Coated Tablets.
• Bisphosphonate (used for the treatment of osteoporosis) or sodium fluoride is used concomitantly with Accrete D3 1500mg/400iu Film-Coated Tablets, these preparations should be administered at least three hours before using Accrete D3 1500mg/400iu Film-Coated Tablets.
• Rifampicin (a medicine for tuberculosis), phenytoin (a medicine for epilepsy) and barbiturates (medicines which are used for epilepsy or which help you sleep), as they may make the vitamin D3 less effective.
• Quinolone (antibiotics), as calcium may interfere with its absorption. Quinolone antibiotics should be taken two hours before or six hours after intake of calcium.
• Estramustin (a medicine used in chemotherapy), thyroid hormones or medicines containing iron, zinc or strontium, as the amount absorbed may be reduced. They should be taken at least 2 hours before or after Accrete D3 1500mg/400iu Film-Coated Tablets.